Endocrine Abstracts

Objective: The presence of APA has been reported in patients with autoimmune polyendocrinopathies, but their prevalence in type 1 diabetes mellitus (T1D) is still unknown. The aim of this study was to assess APA prevalence in T1D patients as compared to patients with type 2 diabetes mellitus (T2D) and healthy subjects.Research design and methods: The presence of APA was assessed by indirect immunofluorescence (IF) technique, with bovine adrenal gland and...

GH and insulin-like growth factor 1 (IGF1) are known to promote breast carcinogenesis. Breast cancer (BC) incidence in not increased in female acromegalic patients, but mortality is greater as compared to general population. We previously demonstrated that GH/IGF1 excess influences BC response to therapy, possibly accounting for the increased mortality. We indeed showed that GH and IGF1 induce cell proliferation of a BC cell line, the MCF7 cells, providing protection towards t...

Serotonergic transmission is involved in eating behaviour and body weight control. Comparison of SERT properties in blood platelets and serotonergic synaptosomes suggests that the human platelet can serve as an appropriate model for the transport, metabolism and release of serotonin by serotonergic neurons.Aim of this study was to evaluate SERT expression in platelets obtained from overweight or obese subjects (OB) as compared with normal weight healthy volunteers (C), and to ...